Protective role of Lactobacillus plantarum A7 against irinotecan-induced genotoxicity

Protective role of Lactobacillus plantarum A7 against irinotecan-induced genotoxicity

OBJECTIVE Irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. The present study evaluated the effect of Lactobacillus plantarum A7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (HepG2) by comet assay. MATERIALS AND METHODS HepG2 were incubated with irinotecan (100 µM), heat-killed cells (0.025 µg/ml) + irinotecan...

protective role of lactobacillus plantarum a7 against irinotecan-induced genotoxicity

objective: irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. the present study evaluated the effect of lactobacillus plantarum a7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (hepg2) by comet assay. materials and methods: hepg2 were incubated with irinotecan (100 µm), heat-killed cells (0.025 µg/ml) + irinotecan...

The Protective Role Of N-Acetylcysteine Against Acrylamide-Induced Genotoxicity And Oxidative Stress In Rats

Lipocalin2 Protects Human Embryonic Kidney Cells against Cisplatin–Induced Genotoxicity

Cisplatin is one of the most useful chemotherapeutics which performs its cytotoxic effectvia accumulation of platinum resulting in oxidative stress, and destruction of cell DNA. Thiscould probably cause secondary cancers in healthy tissues. Lipocalin2 (Lcn2) is a protein whichits expression is increased in oxidative stresses. Therefore, the present study was performedto evaluate the protective ...

protective role of diallyl disulphide compound (from garlic extract) against mercuric chloride - induced genotoxicity and cytotoxicity in albino rats

abstract mercury compounds are widely used in several industries. such compounds can find their way to the environment causing its pollution. mercury is considered as a powerful carcinogenic agent. on the other side, the garlic extract is characterized by having compounds of specific anticarcinogenic action. therefore, the present study was conducted to investigate both the genotoxicity and cyt...

Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish

The consumption of probiotics has become increasingly popular as a means to try to improve health and well-being. Not only are probiotics considered beneficial to digestive health, but increasing evidence suggests direct and indirect interactions between gut microbiota (GM) and the central nervous system (CNS). Here, adult zebrafish were supplemented with Lactobacillus plantarum to determine th...